Boc-iminodiacetic acid

Boger DL, Goldberg J, Satoh S, Ambroise Y, Cohen SB, Vogt PK, Non-amide based combinatorial libraries derived from N-Boc iminodiacetic acid Solution-phase synthesis of piperazinone libraries with activity against LEF-l//l-catenin-mediated transcription, Helv. Chim. Acta, 83 1825-1845, 2000. 

Another general method for the synthesis of these macrocycles is the reaction of amines with (active) esters of carboxylic acids leading to oxoderivatives of the cycles. The amides can be reduced to amines or directly used for further transformations or complexation of metal ions. Two cyclens 55 and 56, as intermediates for the synthesis of bifunctional DOTA derivatives, were obtained by condensation shown in Scheme 10 between appropriate diamine-amide and active ester of AT-BOC-iminodiacetic acid (BOC = /-butoxycarbonyl), followed by deprotection and reduction <2003NMB581>. 

Boc-iminodiacetic acid monoamides primary, secondary aliphatic, primary aromatic aminesb) acid/ PyBOP hydroxy, ester, acylamino 7, 13, 14, 21,95, 123, 132]... 

---