Blood oxygenators complements

Soliris is for the treatment of paroxysmal nocturnal hemoglobinuria (PNH). PNH is a chronic disease where a patient s oxygen-carrying red blood cells are missing the normally present complement inhibitors. The cells are therefore abnormally fragile and inadvertently destroyed by normal complement activation. 

The heart is a supreme example of biomechanical engineering, and, under normal circumstances, it operates with elegant economy (Turner 1994). As acute metabolic demand varies with increases and decreases in skeletal muscular activity, cardiac activity adapts commensurately, enabling skeletal musculature to receive appropriate supplies of blood, and hence oxygen, to facihtate its physical activity. This intimate and biologically sensible arrangement is complemented by blood flow within the systemic vasculature, which (under normal circumstances) ensures adequate oxygen supply to all bodily tissues. 

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