Blood Half-Life and Organ Distribution of PEG-Coated Nanospheres

BLOOD HALF-LIFE AND ORGAN DISTRIBUTION OF PEG COATED NANOSPHERES 

To further improve blood circulation time, it would be necessary to further increase the molecular weight of the PEG coating, but when one does so, PEG loses its elimination properties. An alternative is to use shorter PEG chains but maximize the surface density. 

To study the influence of PEG surface density, a series of nanospheres were prepared with PEG5K-PLGA copolymers with different PLGA chain 

The sum of the biodistribution results obtained with two animal models (mice and rats) and on different PEG-coated nanoparticles (PEG-R and 

PLGA coated with PEG-PLA, labeled with In or [ CJ-PLA) have shown that PEG R copolymers can be successMly used to produce or coat biodegradable nanospheres and thus obtain sterically stabilized particles with dramatically increased blood half-lives and decreased hepatic uptake as compared to naked PLA or PLGA nanospheres. 

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