Blood Flow—a Role for Endogenous Prostacyclin

Cerebral Blood Flow—a Role for Endogenous Prostacyclin  

Has the cerebrovascular synthesis of prostacyclin a role in the modulation of cerebrovascular reactivity or does it act solely in its capacity to repel intracerebral platelet deposition and aggregation  

Many other workers have now confirmed these cerebrovascular properties of indomethacin in other species, including man (Table 2). Methodological factors may explain the discrepancies in the literature. Dawson and Dalessio (1968) employed an inhalation xenon technique for the measurement of human CBF but made no correction for either arterial recirculation of %enon or for the slow extracerebral component of the washout curves. The depression of cerebrovascular reactivity by barbiturate 

Baboon Pickard and MacKenzie 1973 Pickard et al. 1977 b, 1980d Branston et al. 1981 McCalden et al. 1984  

Man Amano and Meyer 1981 Wennmalm et al. 1981 Okabe et al. 1983 Eriksson et al. 1983 Pickles et al. 1984 Dawson and Dalessio 1968 

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Cerebral Blood Flow—a Role for Endogenous Prostacyclin . 32... 

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