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Bleomycin base propenal formation

Ajmera S, Wu JC, Worth J, Rabow LE, Stubbe J, Kozarich JW (1986) DNA degradation by bleomycin evidence for 271-proton abstraction and for C-O bond cleavage accompanying base propenal formation. Biochemistry 25 6586-6592... [Pg.448]

McGall GFI, Rabow LE, Ashley GW, Wu SH, Kozarich JW, Stubbe J (1992) New insight into the mechanism of base propenal formation during bleomycin-mediated DNA degradation. J Am Chem Soc 114 4958-4967... [Pg.466]

Wu JC, Kozarich JW, Stubbe J (1985a) Mechanism of bleomycin evidence for a rate-determining 4 -hydrogen abstraction from poly(dA-dU) association with the formation of both free base and base propenal. Biochemistry 24 7562-7568... [Pg.481]

While the degradation of DNA in vitro by bleomycin - Fe2+ has been firmly associated with the generation of base propenal species, it is now reported that a small amount of 8-hydroxyguanine is also formed in the DNA, in a dose-dependent manner. O Curiously, using bleomycin - Fe2+ with Ehrlich ascites cells in culture, no base propenal or 8-hydroxyguanine formation could be demonstrated, even in conditions of quantitative cell kill. The green complex of bleomycin A2 and cobalt... [Pg.288]

See other pages where Bleomycin base propenal formation is mentioned: [Pg.776]    [Pg.34]    [Pg.288]    [Pg.83]    [Pg.151]    [Pg.434]   
See also in sourсe #XX -- [ Pg.386 ]



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