Bladder saccharin-induced cancers

Figure 2. Dose—response curve for saccharin-induced bladder tumors in rats. Dose is expressed as per cent saccharin in the animals diets. Response (risk) is the fraction of animals in each dosed group developing bladder tumors over their lifetimes - also called the lifetime probability of bladder cancer. Data were reported by Taylor and co-workers, Toxicology and Applied Pharmacology, Vol. 29, page 1S4 (1974).

$Figure 2. Dose—response curve for saccharin-induced bladder tumors in rats. Dose is expressed as per cent saccharin in the animals diets. Response (risk) is the fraction of animals in each dosed group developing bladder tumors over their lifetimes - also called the lifetime probability of bladder cancer. Data were reported by Taylor and co-workers, Toxicology and Applied Pharmacology, Vol. 29, page 1S4 (1974).$

It is recommended that daily saccharin intake be maintained below 1 g because of a risk of bladder cancer. A lifetime daily diet containing 5-7.5% saccharin has induced bladder tumors in rats [69]. However, it is probable that saccharin is only a very weak carcinogen in humans. The amount contained in pharmaceutical preparations is well below the recommended maximum human daily intake. [Pg.671]

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