Blaberus discoidalis

Since that time many more sequences have become available through the advent of recombinant DNA technology and the deduction of amino acid sequences from the base sequences of cloned DNA. At the present time, the primary structures (amino acid sequences) of 14 proteins of the transferrin family have been established. These include seven serum transferrins, from human 10, 36), pig (37), horse 38), rabbit 39), toad Xenopus laevis) 40), sphinx moth (M. sexta) 13), and cockroach Blaberus discoidalis 4) chicken 34, 35) and duck 41) ovotransfer-rins four lactoferrins, from human (11, 42), mouse 43), pig 44) and cattle 45, 46) and the human tumor cell melanotransferrin 47). All of these sequences are available from sequence databases such as EMBL and SWISSPROT. 

Figure 7. Proposed active structure for Bld-HrTH for hypertrehalosemic activity in Blaberus discoidalis cockroaches.

T. K. Hayes, L. L. Keeley, and D. K. Knight, Biochem. Biophys. Res. Commun., 140, 674 (1986). Insect Hypertrehalosemic Hormone Isolation and Primary Structure from Blaberus discoidalis Cockroaches. 

Bacillus, 350 Bacillus rossius, 350 Blaberus discoidalis, 359 Bombina variegata, 106 Bombyx mori, 98, 118 Bradijsia elegans, 116 Bufo americanus, 106 Bufo bufo, 5, 106 Bufo valliceps, 106 Bufo viridis, 108 Bufo woodhousei fowleri, 106... 

Lee Y, Keeley LL. Intracellular transduction of trehalose synthesis by h3fpertrehalosemic hormone in the fat body of the tropical cockroach Blaberus discoidalis. Insect Biochem Mol Biol 1994 24 473 80. 

Figure 2. Dose-response effects by Blaberus hypertrehalosemic hormone on in vivo synthesis of trehalose (upper) and cytoheme ab (Iowct) in decapitated, adult male B. discoidalis.

Figure 3. Effects of bioanalogs of Blaberus hypertrehalosemic hormone on cytoheme ab synthesis in the fat body of 4-day old, adult male B, discoidalis. Values are mean+SEM. All animals were decapitated on day 0 and received 20 pmoles of peptide on days 2,3 and 4 followed by measurement of cytoheme cb synthesis on day 4.

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