Bjerrum method procedure

Method 1 (Lund and Bjerrum, 1931). The procedure depends upon the reactions ... 

An initial step in data analysis is to develop an equation that represents the experimental data reasonably. Although previous sections dealt with this issue, the approach assumed that certain species are formed. Two alternatives to this procedure are discussed here, both yielding the approximate stoichiometry of the complexes formed in the system. The most elementary is referred to as Job s method, while the ligand number method, developed by J. Bjerrum, is slightly more advanced. 

Avdeef (1998) has reported an automated potentiometric titration method for the determination of solubilities of drug substances containing ionizable groups, where a graphical procedure is used for the estimation of solubility constants based on Bjerrum difference plots. One useful relation derived in this work was ... 

Procedures for preparing most of these salts were originally submitted by Dr. McReynolds, who was impressed by the simplicity of Dr. Bjernim s method. Shortly after the manuscript for VoL II had been sent to the publisher, similar procedures for three of these salts were submitted by Dr. Bjerrum. Inasmuch as the method was developed by Dr. Bjerrum and war conditions prevented bis submittii the procedures at an earlier date, the editors have taken the liberty of combining the two sets of directions and presenting them as a joint effort of the two men. 

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