Bitolterol 3-agonist

The P2 selective adrenergic agonists are most widely used drugs for the treatment of asthma. They are effective after oral and inhaled administration and have a longer duration of action. Albuterol (salbutamol), salmeterol, bitolterol, pir-buterol are available as aerosol pack in metered dose. 

Applications of p-Agonists. Most of the j3-selective adrenergic agonists, albuterol (13 salbutamol in Europe), bitolterol (14),... 

P Adrenergic agonists, such as albuterol, bitolterol, isoproterenol, metaproterenol, pirbuterol, and terbutaline in the inhaled form, have become the treatment of choice for a short-acting approach to relief of asthma. These drugs are very effective at providing rapid bronchodilation without significant cardiac or systemic effects. Because they are administered in the vapor form, have short time of action, and produce little toxicity, measurement of blood levels offers little clinical benefit patient response provides a convenient form of monitoring therapy. 

Metabolic processes in the lung may be exploited in drug design, as is the case for bitolterol. This compound is administered as an inactive ester that must be hydrolyzed by tissue-associated esterases to form the active (32-adrenoceptor agonist colterol [143]. This process takes several hours and results in a long duration of action of the bronchodilator. 

Inhalational selective beta2-adrenergic receptor agonists (albuterol, terbutaline, fenoterol, and bitolterol) have a rapid onset of action and are effective for 3 to 6 hours. Formoterol and salmeterol are longer-acting agents (12 hours) and may prove useful in treating nocturnal symptoms. 

Beta-2 adrenoceptor agonists Inhaled Short-acting Bitolterol, Clenbuterol, Fenoterol, Levosalbutamol, Pirbuterol, Procaterol, Reproterol, Salbutamol (Albuterol), Terbutaline, Tolubuterol Long-acting Arformoterol, Formoterol, Salmeterol... 

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