Bisulfite reaction with uridine

Reactions of nucleophiles. A number of nucleophilic reagents add reversibly at the 6 position of pyrimidines. Thus, bisulfite adds to uridine (Eq. 5-10).528 Hydroxylamine (HONH2) adds in a similar fashion to give a compound with -HNOH in the 6 positions.528 Sodium borohydride (NaBH4), which can be viewed as a donor of a hydride ion (H ), reduces uridine to the 5,6-dihydro derivative. This presumably occurs by attack of the hydride ion at position 6 in a manner analogous to the reaction of bisulfite in Eq. 5-10. 

The 5,6-double bond in uracil, 5-fluorouracil, A-alkyluracils, thiouracils, and uridines is involved in adduct formation with sodium sulfite or bisulfite to give the corresponding 5,6-dihydro- 6-sulfonic acid salts. Bisulfite addition to cytosines and cytidine may be succeeded by a second reaction involving nucleophilic replacement of the amino group, for example, by water . 

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See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

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