Bisnicalaterines

Nugroho AE, Hirasawa Y, Kawahara N, Goda Y, Awang K, Hadi AHA, Morita H (2009) Bisnicalaterine A, a vobasine-vobasine bisindole alkaloid from Hunteria zeylanica. J Nat Prod 72 1502-1506... 

Bisnicalaterine A (45), consisting of two vobasine-type units, was isolated from the leaves of Hunteria zeylanica (Apocynaceae), together with two... 

Bisnicalaterines B (142) and C (143) were isolated from the bark of Hunteria zeylanica (Apocynaceae) (Figure 23). Both compounds consisted of the same ebuman and Corynanthe units that were connected via C-16 in the ebuman unit and C-9 in the Corynanthe unit. Their stmctures including their absolute configurations were established by NMR, CD, and computational methods. Bisnicalaterines B (142) and C (143) were a pair of atro-pisomers and showed potent vasorelaxant activity on isolated rat aorta. 

Two new indole alkaloids, bisnicalaterine D (1), consisting of an ebumane and a corynanthe type of skeletons, and nicalaterine A (2) were isolated from the bark of Hunteria zeylanica. Their structures were elucidated by various spectroscopic data such as NMR and CD spectra. A series of bisnicalaterines and nicalaterine A showed potent anti-plasmodial activity against P. falciparum 3D7 [28]. 

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