Bisdimethylaminofluorophosphine oxide

It was found that tetramethylphosphorodiamidic fluoride (bisdimethylaminofluorophosphine oxide) was very toxic and had a l.d. 50 of the order of 1-0 mg./kg. for subcutaneous injection into mice the concentration for rabbits was higher at 3 0 mg./kg. (intravenously). The Cambridge figure for toxicity by inhalation agreed with that found by American workers, the L.c. 50 for mice being 0 095 mg./l. for a 10 min. exposure. We also carried out experiments with four human observers exposed to a concentration of one part in a million for 5 min. No effects of any kind were noted in particular, myotic action was absent. In this report, therefore, the highly toxic compound... 

The chemical found to be the most effective to date for the control of the mealy bugs is dimefox (bisdimethylaminofluorophosphine oxide). This is the active ingredient of the commercial product Hanane produced by Pest Control, Ltd., London, which holds a contract for investigation and control of swollen shoot viruses. Hanane is applied to the soil around the roots of the trees and a very significant reduction in the mealy bug population has been obtained by this method. 

Bisdimethylaminofluorophosphine and alkyl- or aryldialkylamino-fluorophosphines can also be readily oxidized by halogens (86)... 

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