Bisabolane: ar-turmerone

Four anti-tumor bisabolane sesquiterpenes, a-curcumene (224), ar-turmerone (225), P-atlantone (226) and xanthorrhizol (227), were isolated from the rhizomes of C. xanthorrhiza and 224 was reported to be the most active compound [170]. On further examination of the rhizomes, four additional bisabolanes, bisacurone (228), biscumol (229), bisacurol (230) and curlone (231) were obtained [171]. The absolute stereostructures of compounds 228-231 were determined by spectroscopy methods, chemical conversions and the CD exciton chirality method for allylic alcohols [171]. In more work by the same group, four related sesquiterpenes, bisacurone epoxide (232), bisacurone A (233), bisacurone B (234) and bisacurone C (235) were isolated from the same extract and their stereostructures were... 

A number of relatively short and straightforward syntheses of bisabolane sesquiterpenoids have been reported these include E- and Z-a-bisabolene, (69) and (70) (together with the isopropenyl analogues),a-curcumene (71),/S-curcumene (72), ar-turmerone (73), iso-a-curcumene (74), ... 

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