Bis -methylamine

The l,4-cyclohexane-bis(methylamine) feed line was connected to the top of the preheater in a pyrolysis tube. The pyrolysis section was heated by external electric heaters. For a typical run, the pyrolysis temperature was... 

In the case of terpyridine and acridine derivatives, the bis(methylamines) are the most convenient intermediates. Substituted 4/-phenyl-2,2/ 6/,2"-terpyridines were prepared by reacting (ii)-propenons and iV-[2-(pyrid-2 -yl)-2-o octln l p ridinium iodide with ammonium acetate in acetic acid or in methanol. The terminal pyridine moieties were oxidized with 3-chloroperbenzoic acid to iV, A" -dio idcs followed by modified Reisserty-Henze reaction to obtain 6,6"-dicarbonitriles. The bis(methylamines) were obtained by reduction of the 6,6"-dicarbonitriles withborane (scheme 8 (Mukkala et al., 1993)). 

Finally, the tetraacetate derivatives were synthesized from the bis(halogenomethyl) derivatives and iminobis(acetate) or from the bis(methylamines) and bromoacetate, and then were hydrolyzed to the target tetra(acetic acid) (scheme 9). 

Lu 3-010 (3,3-dimethyl-l-(3-methylaminopropyl)-l-phenylphthalan), a specific blocker of catecholamine uptake devoid of anticholinergic activity, inhibited both basal and pentagastrin stimulated secretion in the rat.88 studies by Lippmann on Lu 3-010 and another series of com-pounds 9 related to N,N -bis-(l-naphthylmethyl)-l, t-cyclohexane-bis-(methylamine) dihydrochloride (AY 9928) suggest that direct correlation between blockade of catecholamine uptake and antisecretoiy effect is moot. 

The numbers of ligands are indicated by Greek numerical prefixes (di, tri, tetra, penta, hexa, etc.). Where these would create ambiguity, multiplicative prefixes (bis, tris, tetiakis, pentakis, hexakis, etc.) and brackets are used, e.g. bis(methylamine). 

The diammoniate of borane carbonyl was first prepared by BURG and SCHLESINGER in 1937(1). Using chemical and spectroscopic methods CARTER and PARRY (2) showed that the closely related bis-methylamine adduct of borane carbonyl is a methyl ammonium salt of a new N-methyl borano-carbamate anion ... 

Careful interpretation of an unexpected biological activity led to the discovery in the Ayerst Laboratories of a totally new type of hypocholesterolemic agent. Humber and co-workers [337] were engaged in the exploration of mevalonic acid analogs as potential inhibitors of cholesterol biosynthesis and, as a result, made use of the known technique of purification of their oily acids via their crystalline salts with iV,iV -dibenzylethylenediamine (CXLVI). In due course it was discovered that some of the new acids were only active in salt form. Indeed, the dihydrochloride of the base CXLVI was found to inhibit the incorporation of mevalonic acid into cholesterol by rat liver homogenates at a concentration of 1X moles [338]. This observation led to the synthesis of a great number of diamines. A dramatic increase in the hypocholesterolemic activity was observed with compounds containing the rans-l,4-cyclohexane-bis(methylamine) moiety. Subsequent chemical modifications led to the development of r iws-l,4-bis(2-chlorobenzylaminomethyl)-cyclohexane, AY-9944 (CXLVII) [339, 340]. 

Condensations of keto-esters (177) with o-phenylene-bis-methylamine afford the pyrido- and pyrrolo-benzodiazepines (178a) and (178b), although entry into... 

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