2.5- bis hydroxymethyl

Chlor-3-amino-2-methyl-4,5-bis-[hydroxymethyl]-pyndin-Hydrochlorid 44% d.Th. F 270°... 

Aus der Mutterlauge erhalt man nach Zugabe von Salzsaure 0,0129 g (14% d.Th.) 3-Hydroxy-2-methvl-4,5-bis- hydroxymethyl]-pyridin-Hydrochlorid. 

Benzylimino-l-iithoxy- 83 trans-4,5-Bis-[chlorcarbonyl]- 186 trans-4,5-Bis-[hydroxymethyll- 179, 186 3-Brom- 505, 668 l-(4-Brom-butyl)- 401 l-[Buten-(3)-ylJ- 70 1-Butyl- 670... 

Aryl-758 und 2-Alkyl-imidazole759 werden durch Formaldehyd mit Alkalimetallhydroxiden oder tertiaren Aminen als Katalysator in Wasser oder Alkoholen in guten Ausbeuten zu den entsprechenden 2-substituierten 4,5-Bis-[hydroxymethyl]-imidazolen umgesetzt. 2,4(5)-Disubstituierte Derivate werden analog in 5(4)-Position hydroxymethyliert758. 

Synonyms. Adermine Pyridoxol Vitamin B6. 3-Hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridine C8HhN03 = 169.2 CAS—65-23-6... 

METHYL-4,5-BIS(HYDROXYMETHYL)-3-HYDROXYPYRIDINE see PPK250 P-METHYLBIVINYL see IMSOOO METHYL BORATE see TLNOOO xMETHYLBROMID (GERMAN) see MHR200 METHYL BROMIDE see MHR200... 

METHYL-3-HYDROXY-4,5-BIS(H DROXYMETHYL)PYRIDINE see PPK250 2-METHYL-3-HYDROXY-4,5-BIS(HYDROXYMETHYL)PYRIDINE HYDROCHLORIDE see PPK500... 

Reductive procedures are seldom sufficiently specific to give high yields of pure aldehydes, and so it is customary to reduce an ester function with lithium aluminium hydride to hydroxymethyl and then reoxidize [11]. A range of 1-substituted 4,5-dicarbethoxyimidazoles have been reduced to the 4,5-bis(hydroxymethyl) derivatives in 50 88% yields oxidation to the bis-aldehydes is reported with 35-45% efficiency [8]. 

Bis(hydroxymethyl)-l,3-dithiole-2-thione 454 could be easily transformed into the dibromide 207 with phosphorus tribromide <1998CC361>. The reaction of the latter with tosylamide afforded the dihydropyrrole derivative 456, which was dehydrogenated with DDQ to produce 457. Treatment of 207 with -butylamine in the presence of cesium carbonate led to A - -butyldihydropyrrole 455 (Scheme 65) <2000JOC5794>. 

Brnalt, J., Kvarnstroem, I., Classon, B., Samuelsson, B. Synthesis of [4,5-Bis(hydroxymethyl)-1,3-oxathiolan-2-yl]nucleosides as Potential Inhibitors of HIV via Stereospecific Base-induced Rearrangement of a 2,3-Epoxy Thioacetate. J. Org. Chem. 1996, 61, 3604-3610. 

Hydroxy-4,5-dihydroxymethyl-2-methylpyridlne hydrochloride. Adenmin hydrochloride Aderomine hydrochloride Ader-oxin Aderoxine AI3-19016 Alestrol Becilan ilan Beesix Benadon Bendectin 4,5-Bis(hydroxymethyl)-2-methylpyridin-3-ol... 

Pyridoxine (peer-ih-DOCK-seen) is also known as 3-Hydroxy-4,5-bis(hydroxymethyl)- -methyl pyridine 3-hydroxy-4,5-dime-thylol-2-methylpyridine and vitamin B6. It is a white, odorless, crystalline compound with a slightly bitter taste. The term pyridoxine is also used as a generic term for three compounds with biological activity classified under the term Vitamin Bfc. The three compounds are pyridoxine, pyridoxal, and pyridoxamine. Pyridoxine is usually produced commercially as the hydrochloride, CH3CSHN(0H)(CH20H)2-HC1, which has somewhat different physical characteristics from pyridoxine itself. 

Pyridoxol 210 (pyridoxine, 3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridine, vitamin B6) was formerly known as adermine (Kuhn 1938) because vitamin B5 deficiency causes skin diseases in animals. Pyridoxal (211, R = CHO) and pyridoxamine (211, R = CH2NH2) also belong to the vitamin B group. Pyridoxal phosphate 212 is a coenzyme for many of the enzymes involved in the metabolism of amino acids. Nicotinamide adenine dinucleotide 213 (NAD , reduced form NADH) is a component of oxidoreductases (for its action see p 293, synthesis see p 131). 

Pyridoxines. An obsolete collective name for pyridine derivatives with vitamin B5 activity. According to lUPAC rule M-7 the name P. should only be used for 4,5-bis(hydroxymethyl)-2-methyl-3-pyridinol and its esters and ethers. The name vitamin B5 is recommended as collective name for P., pyridoxal, pyridoxamine derivatives, etc.. 

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