Bis , conjugated

Bugaut, A. Bathany, K. Scmitter, J.-M. Rayner, B. Target-induced selection of ligands from a dynamic combinatorial library of mono- and bi-conjugated oligonucleotides. Tetrahedron Lett. 2005, 46, 687-690. 

Aspects of phosgene metabolism have been periodically reported, particularly as an active metabolite of chloroform. It will react with two molecules of glutathione to form a bis conjugate (63) and with cysteine to form 2-oxothiazolidine-4-carboxylic acid (64), but it does not appear to have been established if significant amounts of these or related compounds are excreted in urine. As an active metabolite of chloroform, phosgene reacts with the polar heads of phospholipids (65). Its reactions with blood proteins are described in Part B. 

Smith, J. T., 1996, Conservative modeling of 3-D electromagnetic fields Part II Bi-conjugate gradient solution and an accelerator Geophysics, 61, 1319-1324. 

In the work of Lindborg et al [119], the resulting linear equation systems were solved with preconditioned Krylov subspace projection methods [166]. The Poisson equation was solved by a conjugate gradient (CG)-solver, while the other transport equations were solved using a bi-conjugate gradient (BCG)-solver which can handle also non-symmetric equations systems. The solvers were preconditioned with a Jacobi preconditioner. 

A series of bis-conjugates (107) derived from a combination of NSAIDs (98, 99, 101, 102) with acetaminophen bound to amino acid linkers (105, ex-104) were found to be more effective than the parent NSAIDs and to exhibit fewer adverse side effects (Scheme 28) (2014OBC7238). Using this hybrid concept, metronidazole conjugates were also synthesized in an attempt to target Crohn s disease (2015BMCL2314). 

Basset-Boussinesq-Osceen Form of Newton s Second Faw Bubble Column Bi-Conjugate Gradient... 

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