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Solvent bipolar non-protic

Finally it should be mentioned that a number of nucleophilic substitution reactions of unactivated halides can be made to proceed in bipolar non-protic solvents such as dimethyl sulphoxide (DMSO), Me2S —Oe. No hydrogen-bonded solvent envelope, as in for example MeOH, then needs to be stripped from Ye before it can function as a nucleophile AG is thus much lower and the reaction correspondingly faster. Rate differences of as much as 109 have been observed on changing the solvent from MeOH to Me2SO. Chlorobenzene will thus react readily under these conditions with Me3COe ... [Pg.173]


See other pages where Solvent bipolar non-protic is mentioned: [Pg.98]    [Pg.98]    [Pg.55]    [Pg.55]    [Pg.225]   
See also in sourсe #XX -- [ Pg.81 , Pg.98 , Pg.173 , Pg.252 ]

See also in sourсe #XX -- [ Pg.81 , Pg.98 , Pg.173 , Pg.252 ]

See also in sourсe #XX -- [ Pg.81 , Pg.98 , Pg.173 , Pg.252 ]




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Non-protic

Non-solvent

Protic

Protic solvents

Proticity

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