Biotransformations enantioselective acylation

Some reviews have described elegant examples for the enantioselective acylation of racemic alcohols [14-18]. Here, we have selected some reactions of considerable importance due to different factors attending to the substrate structure, the possibility to scale up the biotransformations, and the enz5mie recycling. 

Although with lipase-catalyzed acylations all types of selectivities including enantiotopic selectivity can be realized [29, 30, 60, 79, 81, 83], there are only a few examples of hydrolase-catalyzed enantioselective biotransformations in real flow-through mode (Figure 9.6). 

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