Biotin end group

Fig. 47. Mannosylated dendrons with biotin end group for E. coli capture. ...

Direct peptide patterning PS-binding peptides with ROD, RGE, and biotin end-group BSA HUVEC Pin-microarrayer to print PS-binding peptides, BSA backfill 2009 [159]... 

JOC Jochum, F.D., Roth, P.J., Kessler, D., and Theato, P., Double thermoresponsive block copolymers featuring a biotin end group. Biomacromolecules, 11, 2432, 2010. 

To bring the nanocontainer to a specific place where it should release its pay-load, targeting is a required approach. Hence, much work has been carried out to attach ligands or antibodies to the hydroxyl end-group of PEG-based assemblies [150,181,243], Biotinylated nondegradable block copolymer assemblies have been shown to attach to surfaces coated with the biotin receptor avidin [146,147, 150,244], Coupling chemistry has been applied to conjugate either an antihuman IgG, or antihuman serum to PEG-carbonate- or PEG-polyester-assembled polymer vesicles [149,245], HIV-derived Tat peptide attached to PEG-PBD polymersomes enhanced the cellular delivery of nanoparticles [246] and increased dendritic cell uptake in vitro [181]. 

Neither catalytic component contains a trace of bound biotin. The biotin prosthetic group is covalently linked to the third component, carboxyl carrier protein (CCP—biotin). As with other biotin enzymes, the bicyclic ring of the prosthetic group resides at the distal end of a flexible 14 A side chain which allows it to act as a mobile carboxyl carrier between the two catalytic centers as illustrated below. A large number of biotin-dependent enzymes which carry out diverse reaction types are now known. All of these reactions proceed through a carboxylated intermediate with the carboxybiotinyl prosthetic group functioning as a mobile carboxyl carrier . 

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