Biosynthesis of Daphniphyllum Alkaloids

Total syntheses of Daphniphyllum alkaloids are still ongoing, and the biosynthesis of Daphniphyllum alkaloids requires thorough studies to elucidate the intermediates and the relevant enzymes. The biological activities of Daphniphyllum alkaloids should be extensively investigated. In addition, plants of the genus Daphniphyllum produce the structurally diverse and complex alkaloids, which should play an important role for the plant itself from the evolutionary perspective. Biological/ecological role of these alkaloids in the life cycle of the plant should be paid much more attentions. 

K. T. Suzuki, S. Okuda, H. Niwa, M. Toda, Y. Hirata, S. Yamamma, Biosynthesis of Daphniphyllum alkaloids. Tetrahedron Lett. 14 (1973) 799-802. 

---