Biostream process

Fig, 7.24 (a) The principle of the Biostream process for continuous electrophoretic separation of proteins. (Courtesy Harwell Laboratory, UK Atomic Energy Authority,)... 

We are going to consider two different operating modes. In the first, a creeping flow predominates between two plane-parallel electrodes. The electrodes are not cooled in this case consequently AT is not a freely selectable process parameter. In the second operating mode, in contrast, the operating conditions are those of the so-called Biostream separator. 

Indeed, the Biostream Separator [111] operates according to this principle. The device consists of two concentric cylinders the inner one is made to rotate in order to generate a Couette flow. We are no longer dealing with a creeping flow, therefore the liquid density, p, is not negligible. The number of process parameters is increased from two to four. These are (1) the rotational speed, n, of the inner cylinder. (2) In addition, as a result of the possibility of cooling the outer cylinder wall, the temperature difference, AT is an additional process parameter which is freely adjustable. 

The Elphor VaP is the most versatile of the instruments and due to its continuous mode of operation it has significant preparative potential. The BIOSTREAM, with lt s large processing capacity. Is a true industrial scale machine which is capable of excellent resolution at high processing rates. The RIEF operates in batch mode, but with an easily variable and potentially very large capacity. The... 

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