Bioseparations monoclonal antibodies

Ameskamp N, Priesner C, Lehmann J, Ltitkemeyer D (1999), Pilot scale recovery of monoclonal antibodies by expanded bed ion exchange adsorption, Bioseparation 8 169-188. 

Bioseparations frequently entail separations of proteins and related materials from biological matrices.1 This book is planned to serve as a handbook of bioseparations, where the primary focus is separations of proteins however, separations of other materials of interest such as nucleic acids and oligonucleotides are also covered to assist the reader in tackling their particular bioseparation problems. Included in this text is a chapter on the separation of monoclonal antibodies, as these materials have found numerous uses in the biopharmaceutical industry. As a matter of fact, in the last few decades, monoclonal antibodies and recombinant antibodies have become one of the largest classes of proteins that have received FDA approval as therapeutics and diagnostics. 

Matejtschuk, P. Baker, R.M. Chapman, G.E. Purification of characteristics of monoclonal antibodies. In Bioseparation and Bioprocessing A Handbook Subramaniam, G., Ed. Wiley-vett Wennihem, Germany, 1998 Vol. II, 223-252. 

Biedermann, K., Sabater, M., Sorensen, J., Fiedler, H., and Emborg, C, Quantitative binding studies of a monoclonal antibody to immobilized protein-A. Bioseparation, 1991, 2, 309-314. 

Yu DQ, McLean MD, HaU JC, Ghosh R. Purification of monoclonal antibody from tobacco extract using membrane-based bioseparation techniques. 7. Membr. Sci. 2008 323 159-166. 

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