Biorefineries single-cell biorefinery

Framework molecules derived from genetically modified single cell or multicellular organisms Integrated biorefinery... 

Figure 9.1 The concept of single-cell biorefinery. A biorefinery is a facility that integrates biomass conversion processes and equipment to produce fuels, power, heat, and value-added chemicals from biomass. A single-cell biorefinery, in our views, is a single-cell factory that can produce multiple products from biomass or its various derived components. The orthogonal design of substrate-product metabolism does not interfere with the host cell s native interactome. Hence, the simultaneous production of different compound can be simply maximized by forward engineering principles with high accuracy of prediction.

Simultaneous substrate utilization is the prerequisite for single-cell biorefinery. The selected microbes must possess the possibility to utilize the multiple compounds in the substrate mixture or biomass hydrolysates. However, to design a single-cell biorefinery system, the coproduction in single cell is necessary. 

Table 9.2 Examples that fit the concept of single-cell biorefinery Strains Substrates Products...

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