Bioreductives hypoxia-activated

The bioreductively-activated, hypoxia-selective DNA-damaging properties found in tirapazamine are not uniqne to this nitrogen heterocycle. Analogous properties have been observed for quinoxaline di-A-oxides snch as 99 and In addi-... [Pg.364]

Tumor hypoxia and bioreductive activation of anticancer prodrugs... [Pg.125]

Tumor Hypoxia and Bioreductive Activation of Anticancer Prodrugs... [Pg.133]

Cu]-ATSM is a bioreductive molecule also being proposed for tumor hypoxia imaging. In a trial including 14 patients with NSCLC treated with radiation and/ or chemotherapy it was shown that the mean tumor-to-muscle activity ratio before treatment was significantly... [Pg.162]

As regards hexopyranosyl systems, 5-substituted-6-azauracil nucleosides of N acetylglucosamine have been prepared, and acetobromoglucose was used as starting material to make the bis(nitroimidazole) 71, in a search for hypoxia-selective antitumour agents with two bioreductively-activated units. ... [Pg.278]

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