Bioreductive trapping

Figure 7. Schematic model of bioreductive trapping in hypoxic tumors.

R. (2001) Bioreduction of AuCLt- ions by the fungus VerticiUium sp. and surface trapping of the gold nanopartides formed. Angewandte Chemie-Intemational Edition, 40, 3585-3588. 

Mukheijee P, Ahmad A, Mandal D, Senapati S, Sainkar SR, Khan Ml, Ramani R, Parischa R, Ajayakumar PV, Alam M, Sastry M, Kumar R (2001a) Bioreduction of AuC14 ions by the fungus, Verticillium sp. and surface trapping of the gold nanoparticles formed. Angew Chem Int Ed 40 3585-3588... 

Inside cells, 2-nitroimidazole acts as a bioreductive molecule. It undergoes a single electron reduction in hypoxic environments, forming reactive radicals that bind to intracellular protein thiols and become trapped (96). Because nitro-imidazole uptake requires intact nitroreductase enzymes, 2-nitroimidazole, in principle, could be exploited to distinguish between normoxic, hypoxic (but viable), and necrotic tissues (90). 

Mukherjee, P., Ahmad, A., Mandal, D., Senapati, S., Sainkar, S.R., Khan, M.I., Ramani, R., Parisdia, R., Ajayakumar, P.V., Alam, M., Sastry, M. and Kumar, R. (2001) Bioreduction of AuCl ions by the fungus, Vertidllium sp. and surface trapping of the gold nanopartides formed. Jingewandte Chemie-International Edition, 40, 3585. ... 

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