Bioreactors batch operation

Bioreactors are operated in discontinuous mode, with a sequential or continuous feed of the substrate (fed-batch operation) or in continuous mode. The choice of the operating mode depends mainly on the reaction characteristics ... 

Bioreactors that use enzymes but not microbial cells could be regarded as fermentors in the broadest sense. Although their modes of operation are similar to those of microbial fermentors, fed-batch operation is seldom practiced for enzyme reactors. The basic equations for batch and continuous reactors for... 

The cultivation of cells and adenovirus propagation in suspension bioreactors has been performed in batch, fed-batch, and perfusion modes. In batch operation, no nutrients are added during the course of growth or infection. Although batch cultures are simple to perform and contamination risks are low, essential nutrients are rapidly depleted from the medium and cell viability decreases [110,121]. 

GROWTH CYCLES OF MICROORGANISMS BATCH OPERATION OF BIOREACTORS... 

Growth Cycles of Microorganisms Batch Operation of Bioreactors 453... 

ILLUSTRATION 13.4 Extended Culture (Fed Batch) Operation of a Well Agitated Bioreactor... 

Because we know the concentrations of substrate and biomass present in the bioreactor at the moment the fed-batch operation begins (0.70 and 26.82 g/L, respectively), we can employ equation (H) to calculate the rate at which substrate is being consumed at this time. 

Figure 113.4 Speciation plots for batch operation of a bioreactor to achieve 98% conversion (21.47 h) followed by fed-batch operation for an additional 48 h while maintaining a constant substrate concentration of 0.70 g/L in the growth medium.

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