Bioprocesses mathematical optimization

There is an increasing interest in technologies that maximize the production of various essential enzymes and therapeutic proteins based on E. coli cultivation. The costs of developing mathematical models for bioprocesses improvements are often too high and the benefits are too low. The main reason for this is related to the intrinsic complexity and non-linearity of biological systems. The important part of model building is the choice of a certain optimization procedure for parameter estimation. The estimation of model parameters with high parameter accuracy is essential for successful model development. 

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