Biomolecules water affecting structure

It has been suggested that water in biological systems has a different structure from that of free water. Thus, Szent-Gyorgyi (the discoverer of vitamin C) was the first to suggest that an icelike structure surrounded proteins and other biomolecules. Cope examined cell hydration and asked whether water is affected by conformational... 

The tendency of nonpolar molecules to self-associate in water rather than to dissolve individually is called the hydrophobic effect. The term is somewhat misleading because it refers to the molecules themselves, where in reality it is due to the H-bonding nature of water, but it is used almost universally, and biochemists often speak of the hydrophobic side chains of a molecule as a shorthand for the complexities of discussing water structure as it is affected by nonpolar constituents of biomolecules. 

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