Biomolecules hydrocarbon derivatives

In addition to cholesterol and its derivatives, a remarkable array of biomolecules are synthesized from isopentenyl pyrophosphate, the basic five-carbon building block. The hydrocarbon side chains of vitamin K2, coenzyme Qjq, and chlorophyll are extended chains constructed from this activated C5 unit. Prenyl groups that are derived from this activated intermediate target many proteins to membranes. 

Most biomolecules can be considered to be derived from the simplest type of organic molecules, called the hydrocarbons. Hydrocarbons (Figure 1.4) are... 

Various conceptual DFT-based reactivity indices in association with some new parameters are successfully employed in the development of stronger QSAR/QSTR models [332]. Deeper correlations of the toxicity of different classes of organic compounds like chlorinated benzenes [333], polychlorinated biphenyls [312, 334—336], and benzidine [337] at DFT level of theory are reported. The toxicity of the polychlorinated biphenyls as well as benzidine is itrfluenced by its electron affinity and planarity. The interactions of the chlorinated benzo-derivatives and benzidine with other biomolecules like nucleic acid/base pairs or aryl hydrocarbon hydroxylase (AHH) receptors are primarily of charge-transfer type, which can be quantitatively assessed from Parr to Pearson formula [254] and can be given as... 

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