Biomolecular disruptions

Bulmus V, Woodward M, Lin L, Murthy N, Stayton P, Hoffman A (2003) A new pH-responsive and glutathione-reactive, endosomal membrane-disruptive polymeric carrier for intracellular delivery of biomolecular drugs. J Control Release 93 105-120... 

Biological recognition elements are chosen because they are able to identify a category of toxic effect such as cellular toxicity, genotoxicity, immunotoxicity, neurotoxicity or endocrine disruption. Table 3.4.3 shows some examples of biomolecular recognition systems used in biosensors and bioassays for environmental monitoring (based on Bilitewski et al., 2000 Brenner-WeiB and Obst, 2003). 

In chemical genomics and proteomics, tiny low molecular weight probe molecules are used to perturb the functions of individual genes and proteins. The functional consequences of that perturbation are then examined and analyzed. By using small, yet relatively complex, molecular structures to disrupt cellular events and behavior, biologists can often pick apart some of the most complex and intricate signaling processes that are operational within cells, and thus provide a biomolecular panoptic that would otherwise be unattainable by purely biological means. ... 

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