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Biomarkers skeletal muscle injury, drug-induced

The lack of tissue specificity of the total serum CK assay and the reliance on histopathology to definitively diagnose drug-induced skeletal muscle injury in preclinical drug development have highlighted the need to identily better biomarkers. Beyond the characteristics desired in all safety biomarkers (reviewed in Robinson et al. (2008)), the ideal skeletal muscle injury biomarker should have a number of specific characteristics. First, it should be specific for skeletal muscle tissue injury and, most importantly, allow the discrimination between cardiac and skeletal muscle... [Pg.408]

NOVEL BIOMARKERS OF DRUG-INDUCED SKELETAL MUSCLE INJURY... [Pg.409]

TABLE 26.1 Circulating Biomarkers of Drug-Induced Skeletal Muscle Injury with Evidence of Potential Utility in Drug Development... [Pg.409]

Vassallo, J. D., E. B. Janovitz, D. M. Wescott, C. Chadwick, L. J. Lowe-Krentz, and L. D. Lehman-McKeeman (2009). Biomarkers of drug-induced skeletal muscle injury in the rat troponin I and myoglobin. Toxicol Sci 111(2) 402-412. [Pg.415]

See other pages where Biomarkers skeletal muscle injury, drug-induced is mentioned: [Pg.407]    [Pg.411]    [Pg.411]    [Pg.411]    [Pg.412]    [Pg.501]    [Pg.503]    [Pg.503]    [Pg.503]    [Pg.462]   
See also in sourсe #XX -- [ Pg.111 , Pg.409 ]



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Biomarkers muscle injury

Drug-induced

Drug-induced skeletal muscle injury

Injury biomarkers

Injury drug-induced

Muscle injury

Skeletal muscle

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