Biomarkers brain AChE

The measurement of inhibition of brain AChE is a valuable biomarker assay for OPs and carbamates and is not jnst an index of exposure. Being an assay based on... 

Taking into account that inhibition of brain NTE and AChE are biomarkers for OPIDN and acute cholinergic toxicity, respectively [26,38], to evaluate the validity of in vitro predictions of the neuropathic potential of OP compounds, inhibition of NTE and AChE in hen brain was studied 24 h after im administration of increasing doses of methyl and butyl derivatives of PhP II compounds MePhP (RIP = 0.4) and BuPhP (RIP = 104.8) [62-64],... 

Acylpeptide hydrolase is a member of the serine hydrolase family. It deacetylates the acetylated N-terminus of polypeptides. Rat brain acylpeptide hydrolase was inhibited 93% at a dose of dichlorvos (4 mg/kg, i.p.) which inhibited AChE only 47%. The in vitro sensitivity of acylpeptide hydrolase to chlorpyri-fosmethyl oxon, dichlorvos, and DFP (IC50) was 6-10 times greater than that of AChE (Richards et al., 2000). Acylpeptide hydrolase is also found in human erythrocytes, where it could potentially serve as a biomarker for low-dose exposure to OP in humans (Quistad et al., 2005), though human cases of OP exposure have not yet been tested for OP-modified acylpeptide hydrolase. 

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