Biomacromolecular structure

In biological systems, H-bond donors and acceptors are predominantly nitrogen and oxygen atoms. However, the n electrons of aromatic systems can also act as acceptors, and H-bonds involving sulfur groups or metallic cofactors are also known. The presence of individual H-bonds in biomacromolecular structures is usually derived from the spatial arrangement of the donor and acceptor groups once the structure of a molecule has been solved by diffractive or NMR techniques. More detailed information about H-bonds... 

For the pharmaceutical scientists who formulate biopharmaceuticals as products with ideal therapeutic effects and storage characteristics, these products ate highly challenging. Because of the unique physicochemical characteristics related to the biomacromolecular structure of biotechnology-based drugs, the formulation of biopharmaceuticals is in many ways different from conventional low-molecular drug formulation. 

In all the cases considered so far, the lattices involved are integral. This property implies the existence of a metric tensor with integral entries, up to one real lattice parameter, as in the cubic case. One finds, in particular, isometric hexagonal lattices (with c = a). Similar and additional properties allow one to speak of strongly correlated biomacromolecular structures... 

CHAPTERS BIOMACROMOLECULAR STRUCTURE PROTEINS TABLE 5.8 continued... 

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