Biologies general assumptions

For this hypothetical comparison of the preclinical development programs for a drug and a biologic it was necessary to make some general assumptions about... 

The common features (the basic effects) searched for in the data space are represented by the factors f. Their extraction from given data is based on the general assumption that only a certain part of the variability of, for example, a biological test can be explained by effects also present in the other variable under consideration, that is, is due to the correlation stracture. As a consequence only so much of variance is considered that a minimum of common factors results. 

Textbooks and courses in general statistics are easily accessible to students of chemistry, physics, biology, and related sciences. Some of the more or less explicitly stated assumptions that one often comes across are the following ... 

The concept of the similarity of molecules has important ramifications for physical, chemical, and biological systems. Grunwald (7) has recently pointed out the constraints of molecular similarity on linear free energy relations and observed that Their accuracy depends upon the quality of the molecular similarity. The use of quantitative structure-activity relationships (2-6) is based on the assumption that similar molecules have similar properties. Herein we present a general and rigorous definition of molecular structural similarity. Previous research in this field has usually been concerned with sequence comparisons of macromolecules, primarily proteins and nucleic acids (7-9). In addition, there have appeared a number of ad hoc definitions of molecular similarity (10-15), many of which are subsumed in the present work. Difficulties associated with attempting to obtain precise numerical indices for qualitative molecular structural concepts have already been extensively discussed in the literature and will not be reviewed here. 

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