Biologically dihydroisocoumarins

Krohn K, Bahramsari R, Florke U, Ludewig K, Kliche-Spory C, Michel A, Aust H-J, Draeger S, Schulz B, Antus S (1997) Dihydroisocoumarins from Fungi Isolation, Structure Elucidation, Circular Dichroism and Biological Activity. Phytochemistry 45 313... 

The structures of four new biologically active nematocidal halogenated dihydroisocoumarins (162-165) isolated from submerged cultures of the wood-inhabiting ascomycete Lachnum papyraceum have been elucidated by spectroscopic methods. The compounds are structurally related to lachnumon and mycorrhizin A, which are also produced by the fungus [198],... 

The xenocoumacins are naturally occurring methylbutylamino-3,4-dihydroisocoumarin derivatives recently isolated by the authors and co-workers from the culture broth of bacteria of the genus Xenorhabdus (ref.l). They were isolated as antimicrobial compounds but were subsequently found to exhibit potent antiulcer activity as well as other biological activities. 

We present here a review of our studies on the isolation, structure elucidation and biological activities of xenocoumacin 1 (1) and 2 (2). As well, we review the work of others on related compounds that contain the 3,4-dihydroisocoumarin ring system. In particular, the AI-77 and amicoumacin compounds, whose chemical structures and pharmacological activity are very similar to the xenocoumacins, will be discussed with respect to their structure... 

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