Biological space family

One of the main problems for the annotation and classification of the biological space is the lack of a standard scheme for all protein families. Even within families, different classification schemes coexist and are being used by different research communities. This aspect hampers enormously any chemogenomic initiative aimed at integrating chemical and biological spaces with novel computational techniques. The following provides an overview of the classification schemes currently in use for the main therapeutically relevant protein families. 

Figure 1 Representation of some of the interfaces between biology and chemistry space (a) the continuum of chemistry space continuum with representative regions of specific biological activity highlighted (b) large combinatorial libraries seek to cover as much space as possible across several biological families but with one core scaffold (c) smaller focused libraries, shown as the small blue cubes, are designed with relevant biological targets in mind and(d) libraries that do not overlap with relevant biological space are undesirable...

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