Biological processes nitric oxide

The chemical biology of nitric oxide (NO) and its derivatives rely heavily on the interaction of this diatom with heme and nonheme iron enzymes. Such interactions are important in the mammalian cardiovascular system as well as in the detoxification of NO in pathogenic microbes. As such, synthetic bioinorganic chemists have designed and constructed a variety of low molecular weight coordination complexes to understand the structural and reactive properties of FeNO systems as they relate to biological processes. Over the last several years, much synthetic work has focused on the construction of FeNO and FeNO complexes as representative models of NO reductase enzymes and as potential nitroxyl- or FINO-releasing molecules for new cardiovascular therapeutics. This review describes the synthesis, structure, spectroscopy, and reactivity of such FeNO systems published from 2011 to 2014. 

Nitrogen monoxide ( nitric oxide ) is another stable free radical. Although known for hundreds of years, NO has only recently been discovered to be an extremely important biochemical messenger and moderator of so many biological processes that it might be better to ask Which ones is it not involved in ... 

In contrast to nitric oxide, which is firmly identified in biological systems and for which numerous (but not all) functions are known, the participation of other nitrogen species in biological processes is still hypothetical. At present, the most interest is drawn to the very reactive nitroxyl anion NOT It has been shown that nitroxyl (or its conjugate acid, HNO)... 

Nitric oxide is important to a wide variety of mammalian physiological processes (1,2), beyond being a constituent of air pollution (3). Natural physiological activities are now known to include roles in blood pressure control, neurotransmission and immune response, and a number of disease states involving NO imbalances have been reported (2,4) as the result of extensive research activity into the chemistry, biology and pharmacology of NO. Understanding the fundamental reaction mechanisms... 

Nitric oxide (NO-) is generated enzymatically from glutamate by the nitric acid synthase and is responsible for a large number of diverse biological processes (for a review, see Nathan 1992 for spin trapping of the ensuing radicals, see Tsai et al. 2000). It was soon realized that an excess production of NO- is toxic, and a part of its toxicity was attributed to its reaction with 02-, i.e the formation of peroxynitrite [reactions (30) and (31)] (Beckman et al. 1990 for a review, see Murphy et al. 1998). 

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