Biological prevalidation

SCONP and PSSC themselves are cheminformatics-and bioinformatics-based approaches for the design of biologically prevalidated compound collections which aim to improve the probability for successful discovery of small molecule ligands and inhibitors. The combined use... 

FIGURE 9.8 Workflow of the BIOS concept incorporation similarity in the protein and the small molecule world and matching both by biological prevalidation. 

Selectivity, a concept related to specificity, is a measure of the extent to which the method can determine the analyte of interest in a biological matrix without interference from other constituents in the test sample (i.e., matrix components). Again, because LBAs determine analytes in the biological matrix without sample pretreatment, this methodology is prone to interference from components present in the sample matrix. Specificity and selectivity evaluations are conducted in prevalidation and confirmed early in prestudy validation. 

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