Biological Iron-Sulfur Clusters with Catalytic Activity

Biological Iron-Sulfur Clusters with Catalytic Activity... 

The discovery of the different dinuclear or cuboidal-type biological iron-sulfur clusters is associated with their natural occurrence in two oxidation states. They can all function as one-electron transferring agents. This redox function has been well established in many studies over a period of almost five decades [1-5], However, electron transfer is generally not considered to be a catalytic activity. It is typically a stoichiometric transfer between two complex redox proteins. Mechanistically, it is probably best described as outer sphere or not involving the breaking and making of covalent bonds other than those related to hydrons. 

This volume begins with a discussion of iron sulfur clusters, a familiar topic to bioinorganic chemists and one that has not lost its appeal. Although long known for their role in biological electron transfer, they have recently been shown also to possess catalytic activity through subsite specific chemistry, wherein one of the iron atoms in the cube catalyzes chemical transformation at its particular corner. To reproduce such disymmetry in an... 

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