Biological Factor Chaperones

In the process of protein folding from the initial sequence to its three-dimensional structure, the cell needs protective molecules called ehaperones. Protein misfolding is due to the malfunctioning of chaperones in biological systems. 

In the crowded cell, chaperones help prevent partly folded proteins from interfering with proper folding. Once a protein is folded and ready to go to work, the chaperone leaves and finds another unfolded protein to protect. Chaperones can also react with misfolded intermediates and restart their folding process from the beginning. It is the chaperone that guides the sequence of amino acids to develop into the three-dimensional stmcture characteristic of normal biological functions. 

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