Biological expression

Many of the planar PAH compounds induce their own metabolism by inducing transcription of the aryl hydrocarbon receptor (Ah receptor). Although expression of CYP1A1 and 1A2 is often coordinately induced, there are clear differences in regulation, not only with respect to substrate specificity but also in their biological expression. For example, CYP1A1 does not appear to be expressed in human liver unless induced,... 

Phenotype—The actual, biological expression in an individual organism of its genetically based information, as influenced by environmental conditions. 

Applications and Practical Examples 15.4.4.1 Biological Expression of GPCRs... 

Maggon K (2004). Rise of biologicals. Express Phurmu. Pulse. February 5,2004. Available http //www.expresspharmapulse.eom/20040205/editorial02.shtml. 

All strategies for the production of genetically engineered polymers rely on the basic principle of self-figation (concata-merization) of DNA monomers to form concatameric DNA sequences (3,4). These concatamers are then cloned into the appropriate plasmid and introduced into a biological expression system, where they are transcribed and translated by the ceUrdar machinery to produce a protein-based pol3nner. 

Biotechnology-derived pharmaceuticals or biopharmaceuticals (BPs) are molecules such as monoclonal antibodies, soluble/decoy receptors, hormones, enzymes, cytokines, and growth factors that are produced in various biological expression systems and are used to diagnose, treat, or prevent various diseases. Safety pharmacology (SP) assessment of BPs has evolved since the approval of the first BP (recombinant human insulin) in 1982. This evolution is ongoing and... 

Fig. 2. Simplified schema for the integration of acid hydrolase biosynthesis and ixissible sites of control Acid hydrolase biogenesis would be determined and controlled genetically via mRNA coding. Full biological expression requires ribosome-imlysome formation, membrane attachment ( stereoorientation) and formation of the enzyme-synthesizing unit...

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