Biological Effects of Carba-sugars

Besides sweetness, a carba-sugar may have biological activity, owing to its structurally close resemblance to a true sugar. 

As mentioned earlier, a-D-carba-galactopyranose (1) has been found in a fermentation broth of Streptomyces sp. MA-4145, as an antibiotic. The potency of the antibiotic was rather low. A concentration of—125 fig/mh is required in order to produce a standard inhibition zone of 25-mm diameter against Klebsiella pneumoniae MB-1264, using 13-mm assay discs in a disc-plate assay. A sample of the synthetic a-DL-carba-galactopyranose (17) was 

Activity of Validamycins and Validoxylamines against Pellicularia sasakii 

Inhibitory Activity (M) of Validamycin and Validoxylamine against Trehalase 

Compound Trehalase inhibitory activity IC (Af) Dendroid test method MIC (/ig/mL) 

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