Biological and Pharmacological Activities of Carbazole Alkaloids

Previously in this series, Kapil (1) and Chakraborty (3) described some of the biological properties of carbazole alkaloids. Since then, a great interest in this area has developed, as attested by some special reviews (7,8,190,192,194,195,255,256,259,260,395-397). In this section, we have summarized some of the important biological and pharmacological activities of this class of alkaloids. 

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A broad structural variety of carbazole alkaloids vdth useful biological activities has been isolated from different natural sources. The pharmacological potential of this class of natural products led to the development of diverse methods for the synthesis of carbazoies [29,30]. We elaborated an efficient iron-mediated construction of the carbazole framework by consecutive C-C and C-N bond formation. This method provides highly convergent routes to carbazoies as demonstrated first for 4-deoxycarbazomycin B (Scheme 15.8) [31]. 

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