Biological activity antibacterial agents

The possession of surface activity per se may be an important faetor in the antibacterial action of a group of drugs, for example the eationie detergents. The addition of low concentrations of surface-active compounds may potentiate the biological effect of an antibacterial agent. Thus, phenols are often more aetive in the presence of soaps. 

Dall Acqua F, see Gambari R (2007) 9 265-276 Daneshtalab M (2006) Novel Synthetic Antibacterial Agents. 2 153-206 Demirkiran O (2007) Xanthones in Hypericum Synthesis and Biological Activities. 9 139-178... 

Pyrrolidines are structural subunits found in many natural and unnatural products, which have important biological activity.102 Depending on the substitution pattern and functionalization, pyrrolidines have been shown to be effective antibacterials,103 neuroexcitatory agents,104 potent venom,105 and glyosidase inhibitors.106... 

Carbadox, a veterinary antibacterial agent, also formed oxidation products when reacted with chlorine [92]. These products are believed to maintain the antibacterial activity because they kept the biologically active A-oxide group in their structure. 

Heterocyclic amines have also been used for aminolysis. Subsequent cyclization of the acylamino amides leads to imidazolones that show a diverse range of biological activities as antibacterial, antifungal, antiviral, antihelmintic, and anti-Parkinsonian agents, as well as central nervous systems (CNS) stimulants. 

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