Bioisosteric context-sensitive

Mining for Context-Sensitive Bioisosteric Replacements in Large Chemical Databases... 

The work presented here follows and builds upon the context-dependent MMP analysis approach described by Papadatos et al. [18]. Specifically, the said approach is employed here in order to detect context-sensitive bioisosteric replacements in a large data set of human liver microsomal metabolic stability data. In what follows, the methodology of this work will be thoroughly described and the results will be discussed in detail. 

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