Biodiversity of Bacterial CYPs and the Actinomycetes

As mentioned earlier, many bacteria, including within the actinomycetes C. diptheriae, possess 

avermitilis and as a pseudogene seen in the dramatic gene decay observed in M. leprae (Table 13.3). 

The diversity of mycobacterial CYPs has been mentioned and trees relating the different CYP families of M. tuberculosis and S. coelicolor indicate they are quite different, reflecting the many hundreds of millions years since divergence from a common ancestor. A list of CYPs of M. tuberculosis is shown in Table 13.2, where the presence of these families in other mycobacteria is also shown. All M. tuberculosis CYPs conform to the expected conserved amino acids within the sequence of a CYP, including a conserved T 

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