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Biodegradable medicinal development

For much of the last century, scientists attempted to make useful plastics from hydroxy adds such as glycolic and lactic acids. Poly(glycolic acid) was first prepared in 1954, but was not commercially developed because of its poor thermal stability and ease of hydrolysis. It did not seem like a useful polymer. Approximately 20 years later it found use in medicine as the first synthetic suture material, useful because of its tendency to undergo hydrolysis. After the suture has served its function, the polymer biodegrades and the products are assimilated (Li and Vert 1995). Since then, suture materials, prosthetics, artificial skin, dental implants, and other surgical devices made from polymers and copolymers of hydroxy carboxylic acids have been commercialized (Edlund and Albertsson 2002). [Pg.186]

The potential of LHRH agonists in human medicine has been gready enhanced by the development of convenient formulations for the delivery of these peptides. The most successful of these have been the biodegradable poly(d,l-lactide-co-glycolide) depot formulations which release the drug over a period of 1-3 months. A biodegradable poly(d,l-lactide-co-glycolide) sustained-release formulation of Zoladex can deliver... [Pg.44]

Several other novel biodegradable polymer systems were also developed. One of these stems from the observation that many polymers used in medicine today were not initially designed for that purpose. It may be particularly useful to have available biodegradable polymers that are composed of, and will break down into, naturally occurring substances. One example is the synthesis of structurally new polyfamino acids) in which L-amino acids or dipeptides are polymerized by nonamide bonds (e.g., ester, iminocarbonate) involving the functional groups located on the amino acid side chains, rather than the extensively used approach involving the amino acid termini. [Pg.16]

Biodegradable nanoparticles have many pharmacentical applications in different areas of human activities like biology and neurology such as targeted drug delivery into the brain for cancer treatment. The developments in bionanoparticles and the nnderstanding of their properties show an optimistic picture in the development of future medicines and related products. [Pg.1151]


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See also in sourсe #XX -- [ Pg.149 ]




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Medicine development

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