Biodegradability probability program

Howard, P.H. and Meylan, W.M. Biodegradation Probability Program, Syracuse Research Corporation, Syracuse, NY (1992). 

The Biodegradability Probability Program has been developed over a period of years and is still being refined. As indicated in Table 12.6, the original model was developed with 35 structural fragments whose coefficients were developed by linear and non-linear regression to an experimental "weight-of- evidence" evaluation for 264 chemicals from the BIO-DEG database (Howard et al., 1987). Chemicals were used only if two or more... 

Biodegradability Probability Program Structural Fragments and Coefficients (Boethling et al., 1994). 

Sample Biodegradation Probability Program Calculations for Benchmark Chemicals. 

Also in the EU TGD (EC, 1996) it is recommended that estimated biodegradability by use of the Biodegradation Probability Program is used only in a conservative way, i.e. when the programme predicts fast biodegradation, this result should not be taken into consideration, whereas predictions of slow biodegradation may be considered (EC, 1996). 

Thus, the use of results of the Biodegradability Probability Program in a conservative way may fulfil the needs for evaluating biodegradability of some of the large number of substances for which no experimental degradation data are available. 

Syracuse Research Corporation. Biodegradation Probability Program (BIOWIN). Syracuse. N.Y. http //esc.syrres.com/ escl/biodeg.htm... 

One of the more popular group contribution QSDRs is a series of models/ collectively referred to as biodegradability probability program (BIOWIN), which consists of six aerobic biodegradation models [6,7,17] and one anaerobic model which has been recently released [18]. These models are available for free from U.S. EPA as part of the EPl Suite (Table 1). 

Syracuse Research Corporation. 1996. BIODEG Program. Estimation of Biodegradation Probability, (computer software for MS-DOS MS-Windows 3.1). http / /esc.syrres.com. North Syracuse, NY. 

To our knowledge, up to this date, five expert systems have been developed that claim capabilities in the field of biodegradation of molecules of diverse structures. They are BIODEG Probability Program (BPP), BESS (Biodegradability Evaluation and Simulation System), MultiCASE (Multiple Computer Automated Structure Evaluation, and META (MULTICASE Inc., P.O. Box 22157, Cleveland, OH44122, USA) and the last one, developed by Gamberger et al. ... 

Predicted using battery method IF the BIOWIN3 (ultimate survey model) result is weeks or faster (i.e., days , days to weeks , or weeks AND the BIOWIN5 (MITI linear model) probability is > 0.5, then the prediction is RB (readily biodegradable). If this condition is not satisfied, the prediction is NRB (not readily biodegradable). BIOWIN3 and -5 are in the BIOWIN program v4.10 (in EPI Suite v4.00). See Section 16.3.3. 

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