Biocompatibility fibrin

A biologic surface that develops an endothelial cell surface is referred to as a neointima. If it is covered with blood components such as fibrin, it is called a pseudointima. In both cases, the surfaces are passive with respect to the blood to which they come into contact. A pseudointima, however, is typically unstable and subject to further ihrombic response. If the surface is damaged, as during surgical implantation, a catastrophic failure can result. This coupled with the difficulty of developing a complete endothelial layer caused one researcher to describe a device as physiologically tolerable rather than biocompatible or hemocompatible. 

An uncoated device would have some thrombus and fibrin coating, but the PC-coated devices are clearly less attractive to blood cells and fibrin. These coatings do not seem to affect endothelialization, and within five days the device is covered with ECs, Potentially, these types of coatings may enhance the safety of the drug-eluting stent, because of the faster endothelialization and because they are more biocompatible. 

Similar to bacterial cellulose, NCC is biocompatible, stable, chemically inactive, and physiologically inert [58]. Moreover, NEC s nanoscale size allows for easy dispersion and its superior strength can provide effective reinforcement to a low strength matrix such as fibrin. These characteristics make NCC a promising nanobiomaterial for SDRVG application. 

Terasaka S, Iwasaki Y, Shinya N et al (2006) Fibrin glue and polyglycolic acid nonwoven fabric as a biocompatible dural substitute. Neurosuigery 58 134—139... 

Bonzon N, Carrat X, Daminiere C, Daculsi G, Lefebvre F, Rabaud M. New artificial connective matrix made of fibrin monomers, elastin peptides and type I + III collagens structural study, biocompatibility and use as tympanic membranes in rabbit. Biomaterials. 1995 16 881-5. 

Fibrin is a biopolymer similar to collagen. It is an important component of the namral blood clotting process. Fibrin has long been used as a biopolymer due to its excellent biocompatibility and rapid bioresorption. It is widely used as a sealant to induce thrombosis and prevent blood loss from wounds. Fibrin also facilitates cell adhesion and proliferation. 

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