Biochemical Mechanism of Alkylphosphonates

These alkylphosphonates lo were expected to be effective PDHc El inhibitors because they were obtained by the chemical modification of sodium (9-methyl acetylphosphonate 1-1, which is a potent PDHc El inhibitor. Therefore, it is interesting to examine inhibitory activity of these alkylphosphonates lo and explore the biochemical mechanism. The inhibition of several alkylphosphonates lo against PDHc was studied through two aspects  

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The biochemical mechanism of herbicidal action of the alkylphosphonates was explored on the basis of biochemical experiments. Representative herbicidal active alkylphosphonates were selected to examine their inhibition against plant PDHc through enzyme activity assays, kinetic experiment, and enzyme-selective inhibition experiment. Based on the above study we can give the following conclusions ... 

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